Below is a short list of some other medications that are processed through the CYP3A4 enzyme. Drug Interactions . However, little conclusive information is available about milk thistle interactions. There are no regulated manufacturing standards in place for many herbal compounds and some marketed supplements have been found to be contaminated with toxic metals or other drugs. Common interactions include insomnia among females and fatigue among males. Early research suggests that milk thistle may decrease the activity of certain liver enzymes. Milk thistle should not be used in place of medication prescribed for you by your doctor. In both studies all subjects will receive the same milk thistle supplement and no placebo will be administered. Although milk thistle helps reduce glucose levels in the blood, meaning that it may be beneficial for patients with diabetes, it is very important to understand that if medication for this condition is taken, this plant should not be taken without medical supervision. A warning about milk thistle (silymarin) and drug interactions. Evidence, mechanism, importance and management See what others have said about Milk Thistle, including the effectiveness, ease of use and side effects. Medications used for lowering cholesterol (Statins)Interaction Rating: Minor Be cautious with this combination.Talk with your health provider. Milk thistle can interact with other medications and conditions. Some cancer drugs. Milk thistle can increase levels of some drugs and can also lower those levels. Early research suggests that milk thistle may decrease the activity of certain liver enzymes. Anti-anxiety drugs. Milk thistle might increase how quickly the liver breaks down some medications. A 44-year-old member asked: Is there a drug interactions between milk thistle and pomegranate? do these drugs interact with milk thistle?" Other drugs may interact with milk thistle, including prescription and over-the-counter medicines, vitamins, and herbal products. USES: Milk thistle has been used for diabetes in combination with standard treatment. Milk thistle + Benzodiazepines. It has also been used for liver disease although it has not been shown to be effective. Some … Milk thistle may excessively lower blood sugar in people on antidiabetic drugs. does milk thistle interfere with any prescription drugs. The phase IV clinical study is created by eHealthMe based on reports of 232 people who take Milk thistle and Metformin from the FDA, and is updated regularly. Herb / drug interactions: The breakdown of milk thistle by certain liver enzymes may interfere with the action of drugs that are metabolized by those same enzymes. Serious Interactions. It seems that the Milk Thistle does have some positive effects when used with Methadone. The phase IV clinical study is created by eHealthMe based on reports of 45 people who take Losartan potassium and Milk thistle from the FDA, and is updated regularly. This excess of drugs could lead to uncomfortable or even dangerous side effects. Milk thistle may raise the levels of a hepatotoxic metabolite of pyrazinamide. If you use protease inhibitors or non-nukes, and take a milk thistle, it may raise levels of these drugs, causing side effects. Does Milk Thistle Interfere With Blood Pressure Medication Hep What Does C. Hepatic synthetic and genetically destroyed Can have high death rates for Asian American groups are several times higher than 80% with medical management 2009, 8:709714 Andrade RJ, Robles M, Lucena MI. Related: PK and drug interactions. Drug Interactions. Do not combine allergy drugs with milk thistle simply because they will be broken down internally by the same exact liver enzymes. Milk thistle is a widely used herbal product that appears to have a relatively low risk of drug interactions. Also question is, what medications does milk thistle interfere with? Published February 24 2014. Always consult your doctor before supplementing and let them know about all drugs and supplements you are using or considering. Please consult a doctor or healthcare professional before trying any remedies. It seems my dose has been holding him better, meaning a full 24 hours. Many meds for people with AIDS, for example, are processed by this liver enzyme. I’ll always be a bit of stubble growth is noticeable. The HCV Advocate says that the lipid-lowering drugs Lescol, Mevacor, Pravachol, Zocor and Baycol all have the potential to interact with milk thistle in this way. The commonly used herbal supplements selected include Echinacea, Ginkgo biloba, garlic, St. John's wort, goldenseal, and milk thistle. These medications may interact and cause very harmful effects. Many physicians recognize that the evidence suggesting milk thistle interferes with certain medications is tenuous, and that there are great benefits of milk thistle for someone with chronic liver disease. Milk thistle does not appear to affect the pharmacokinetics of midazolam. Conclusions: HP (especially ginseng, rhadiola rosea, ginkgo biloba, milk thistle) are associated with a significant risk of pharmacokinetic and pharmacodynamic interactions with psychotropic drugs. Top answers from doctors based on your search: Disclaimer. Levels of these medications may increase if taken by people who are also using milk thistle. Milk Thistle received an overall rating of 0 out of 10 stars from 0 reviews. Milk thistle is often sold as an herbal supplement. This study is also expected to take approximately 8 weeks but will involve 18 clinic visits. Advice is for information only and should not replace medical care. Diabetes Home > Milk Thistle Drug Interactions Although it is a dietary supplement , milk thistle can theoretically interact with medications. Drugs broken down by the liver. Milk thistle can also be taken with cholesterol-lowering medications, like statins. This is an assessment study of the potential for this botanical extract to interact with other prescription or over-the-counter medications. If milk thistle is taken by someone using protease inhibitors or non-nukes, it has the potential to raise levels of these drugs, causing unpleasant or even dangerous side effects. It can help prevent elevation of liver enzymes, which can be a side effect of the medication. A Verified Doctor answered. 30 July 2001. Keep a list of all your medications with you, and share the list with your doctor and pharmacist. There are some possible milk thistle drug interactions to be aware of if you are considering taking this supplement. "Is there a drug interactions between milk thistle and pomegranate?" Not all possible interactions are listed in this product guide. Take milk thistle in capsule, extract or infusion form. Milk thistle (Silybum marianum) is an herbal remedy widely used in HIV-infected patients for the treatment or prevention of liver disease caused by hepatitis and hepatotoxic drugs. Medication Uses | How To Use | Side Effects | Precautions | Drug Interactions | Overdose | Notes | Missed Dose | Storage. Common interactions include rectal haemorrhage among females and fatigue among males. For information on the interactions of individual flavonoids present in milk thistle, see under flavonoids.
Links to other sites are provided for information only -- they do not constitute endorsements of those other sites. Ask doctors free. Milk thistle can interact with some medications. But milk thistle does not seem to affect how quickly the body breaks down indinavir (Reyataz). So yes to taking milk thistle and synthroid or levy, but try to space them out, and not take them together. Allergy Medications . Drug interactions are reported among people who take Milk thistle and Metformin. To account for the possibility of interference with cytochrome P-450, physicians often advise periodic blood tests to determine drug levels instead of skipping silymarin. Therefore, before using this product, tell your doctor or pharmacist of all the products you use. Milk thistle and drug interactions are common problems, but can easily be prevented if you take a look at the 3 main medications that you should NOT mix milk thistle with! Milk thistle may interfere with the following medications, because both milk thistle and these medications are broken down by the same liver enzymes: Allergy drugs. Milk thistle can interact with certain drugs, so check with your GP or a medical herbalist before taking. Not much is known about milk thistle’s food and drug interactions . However, little conclusive information is available about milk thistle interactions. High blood pressure occurs when the artery wall pressure rises above 120 systolic and 90 diastolic, which is measured in millimeters of mercury. Ask doctors free. This document does not contain all possible interactions. Because of the resulting complications and side effects, any decision to include a herbal supplement should be preceded by a detailed safety analysis with benefit and risk assessment. Milk thistle may interact with other drugs. Numerous herbal drug interactions have been reported. The seeds of the milk thistle plant are commonly used to protect the liver from damage caused by hepatitis viruses as well as alcohol and other substances. Milk thistle may reduce your blood sugar, so it needs to be used with caution as it may trigger hypoglycemia (low blood sugar) in people on diabetes medications. Top answers from doctors based on your search: Disclaimer. To date, several significant herbal drug interactions have their origins in the alteration of CYP enzyme activity by various phytochemicals. It does not appear to have much effect on most CYP450 isozymes, although a small effect on CYP2C9 is possible (based on inhibition of losartan metabolism). Find out more on Drug interactions are reported among people who take Losartan potassium and Milk thistle. Drugs for high cholesterol. Answered by Dr. Anne Larson: No Interaction: These medicines do not interact with Milk Thistle. Herb-drug interactions can be dangerous and, in rare cases, even life-threatening. So milk thistle is good for your liver, but it has a lot of iron, and iron interacts with the absorption of your thyroid medication. Does Milk Thistle Capsule Interact with other Medications? It also has oestrogen-mimicking properties, so check if you are pregnant, breastfeeding, or have a history of certain cancers. It may lead to hypoglycemia when combined with diabetes medications such as glimepiride (Amaryl). This list is not exhaustive: Milk thistle is one of the more popular herbs, as it is well known for its role in liver health. A few include: Cholesterol-lowering medications; Allergy medications; Blood-thinning medications; Some forms of cancer treatment; Anti-anxiety medications; Milk thistle may also be a problem with hormonal birth control, hormone replacement therapy, seizure medications, … Answered by a verified doctor: No: No there is not. Compounds found in milk thistle – sylibin, sylimarin – act as antioxidants and also stimulate the repair of the liver. Antiplatelet and anticoagulant drugs (blood thinners). "what do you suggest if my father takes lamivudine and tenofovir for his liver. 1. I have always had an issue with how quickly Methadone metabolizes in his system and even at a 180mg dose would only hold him up to 20-22 hours. Milk thistle (Silybum marianum) is a medicinal plant that has been used for more than 2,000 years in traditional herbal medicine. Blood pressure is defined as the pressure pushed against artery walls as a result of the heart pumping blood. does milk thistle interact with blood pressure medicine. For centuries it was primarily used for the prevention and treatment of conditions related to the liver and/or gallbladder. If possible, wait four hours after you take your meds until you take the milk thistle. Although it is a dietary supplement, milk thistle can theoretically interact with medications. Example, are processed through the CYP3A4 enzyme primarily used for more than years! 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